A wide antibiotic, Miconex pertinent cream, has excellent antimicrobial efficacy over dermatophytes, microbes, and Adelomycetes and high antimicrobial action towards Punnett bacteria and cysts. Treating secondarily infected mycoses is shown to be significantly more effective than other treatments, which either failed or failed again.
Skin or clothing are not stained by Miconex topical cream. A polymeric imidazole antifungal agent called Miconex, the active component has a broad scope of action against pathogenic fungi (including yeast and dermatophytes) and facultative microbes (Staphylococcus and Streptococcus spp).
This could function by changing the microbial vesicles’ breathability. Miconex is a drug that is taken orally but only slightly taken from the digestive tract, peaking at about 1 g daily ml following a daily dose of 1 mg / l. Miconex is inhibited within the system, and between ten and twenty, part of an oral dose is eliminated in the pee in six days, primarily as compounds. A dose intake orally might be excreted in the feces unchanged in about 50% of cases.
The primary mechanism of action of the azole antifungal Miconex is the suppression of a particular demethylase found within the CYP450 complex. The majority of patient reactions to miconazole are limited to cases of anaphylaxis and hypersensitivity because it is typically applied topically, and only very little of it is absorbed into the systemic circulation after application. In order to avoid pregnancy and STDs, it is advised that individuals taking endoscopic antifungal cream medicines avoid using tampons at the same time.
USES
Gram-positive bacteria are resistant to Miconex Topical Cream, making it suitable for use in mycoses secondary to these microorganisms. Face and skin infections like Cellulitis, bcis, under certain pedis, bound, form smaller, unguium or salmonellosis can be brought on by pathogens, microbes, and other microorganisms. Acute stomatitis, otitis eccrine, nail- and epidermis, and impetigo Aspergillus flavus. Miconex Topical therapy, avoidance of intestinal system and nasopharyngeal skin conditions, and superinfections brought on by Facultatively anaerobic bacteria.
Miconex has also been used in conjunction with treatment for the following ailments: Dermatophytosis, nail dermatophytosis, acne vulgaris dermatitis of the diaper, body odor and excessive sweating, fungus infection of the skin, Candida infections of the gastrointestinal tract, mixed infections, fungi of the skin folds, Punish candida ophthalmic candidiasis, Pityriasis Verna, Ringworm, acne seborrheic, facial candida Vaginal Candidiasis, Cutaneous Candidiasis, Tinea Pedis, Tinea Corporis, Tinea Cruris, and Tinea Pedis.
How Miconex works?
Azole antifungal Miconex is used to treat several ailments, including those brought on by an overgrowth of Candida. Miconazole is unique among azoles and is thought to function via three main mechanisms. Suppression of the CYP450 14-lanosterol demethylase gene is the primary mode of action. This alters the production of ergosterol and impairs the composition and permeability of the cell membrane, which in turn causes leakage of cations, phosphates, and low molecular weight proteins.
Additionally, miconazole does not affect the activity of NADH oxidase while inhibiting fungal peroxidase and catalase, increasing the production of reactive oxygen species (ROS). Enhanced intracellular ROS triggers pleiotropic effects that eventually result in apoptosis. Last but not least, miconazole raises farnesol levels within cells, probably as a result of inhibiting lanosterol demethylation. This chemical inhibits the growth of bacteria that are more tolerant of antibiotics, and the transition from fungi to mycorrhizal fungi forms through participating in mediated signaling in Candidiasis.
Farnesol also inhibits the drug efflux ABC transporters CaCdr1p and CaCdr2p in Candida, which may also help azole medications work more effectively.
QUICK FACTS
| Available | only with a prescription. |
| Generic | Miconazole |
| Names of Other Miconazole | Miconazole, Miconazolum, and Monizozol |
| Associated Drugs | Fluconazole, nystatin, clotrimazole, amphotericin B, Diflucan, and itraconazole |
| Weight | 2% |
| Type | Cream |
| Average weight | 416.129 |
| single isotope | 413.986023908 |
| involving protein | Miconazole binds to human serum albumin, according to in-vitro data, but it’s not clear what this finding means clinically. |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Topical Antifungal preparations |
| Manufacturer | ACI Limited |
| Available Country | Bangladesh |
DOSAGE for Miconex
The prescribed intake for oral ingestion is 15 mg/kg/day.
- Adults should take 1-2 teaspoonfuls of gel four times per day, and children over 2. the age of six should take one teaspoonful of gel four times per day.
- toddlers and preschoolers: two teaspoons of gel each day
- Under 2-year-old infants: Half a teaspoon of gel twice daily.
For mouth lesions that are localized:
The affected area can be treated with a clean finger and a small amount of gel. When topically treating the oropharynx, the solution must be kept in the tongue for almost as much as feasible. The treatment plan must continue for at least two days, even after the symptoms have disappeared.
Dental prostheses for mucositis:
Be taken off at bedtime and cleaned with the gel. For all individuals, the quantity remains the same.
For skin infections:
Use a little lotion on the ulcerations daily and gently massage it with your hand until it has fully covered your skin. The majority of lesions typically go away after 2 to 5 weeks. 10 days should be added to the treatment period to prevent relapse.
To treat nail infections:
Quickly clip the affected nail. Once a day, put some cream over the diseased nails with your hand before covering them with a quasi-plastic bandage.
Additionally, the therapy must be followed once the contaminated nails start to loosen (from 2-3 weeks onward) unless a fresh nail has begun to develop and a clear cure is seen (usually after seven months or more).
SIDE EFFECTS
Miconex Nitrate topical application has almost no side effects. Using oral gel There have been sporadic reports of nausea, vomiting, and diarrhea when receiving long-term treatment. Rarely allergic reactions have been documented. There have been a few isolated reports of hepatitis, but it is unknown whether Miconex is to blame.
TOXICITY
Overdoses of Miconex have not been reported as toxic. Patients who overdose are more likely to experience severe side effects like headaches, skin rashes, nausea, vomiting, abdominal pain, and dysgeusia. It is advised to take symptomatic and supportive measures. Miconex has a 500 mg/kg oral LD50 in rats.
PRECAUTION
If using Miconex and anticoagulants simultaneously is planned, the anticoagulant effect needs to be closely watched and dosed. If Miconex and phenytoin are taken together, it is best to keep an eye on the levels of both medications. To prevent the gel from obstructing the throat, caution is necessary, especially in infants and young children. Therefore, the back of the throat should not be treated with gel, and the recommended dosage should be divided into smaller doses. Check the patient for any signs of choking.
INTERACTION
Miconex has the potential to impede the metabolization of medicines by the Cyp450 and -2C9 families. This may cause their effects, including any side effects, to intensify or last longer. Miconex Oral Gel shouldn’t be taken with terfenadine, astemizole, mizolastine, cisapride, tizanidine, oral temazepam, dofetilide, quetiapine, migraine prophylaxis, or CYP3A4 dependent 3-hydroxy-3-methylglutaryl reductase inhibitor including atorvastatin and statins.
Ending up, the topical cream version of Miconex is entirely safe and non-toxic. You don’t need to worry about using it; you only need to take a few safety precautions. All the knowledge you need regarding the cream is now available to you; Learn more by reading the article.